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Anonymous
Dear /an/
Is it possible for random animals to have the downs?
I mean, they surely wouldn't survive too long in nature, but can they be born with the downs?
This is a serious question, it has been bugging me for quite some time now.
Furthermore, if downimals are eliminated by natural selection, why aren't we allowed to kill those disgusting downies?
I think everybody hates them.
>> sausage expert (eaten 356+ kinds of sausage, last: Schwarzwald bratwurst) !GOTHoQ9ES6
>>46487if downimals are eliminated by natural selection, why aren't we allowed to kill those disgusting downies?
Fuck you, nobody hates downies but you. >:(
>> Anonymous
i was wondering this also, except for the whole genocide bit that is...
>> Anonymous
>>46494
get back to eating your Bratwurst, fucker.
We are determined by nature to hate retards, and everybody who has had to deal with them says that they are not only extreme perverts but also have no feelings for right or wrong.
Everyone who denies hating them is a fraud and a filthy lier!
>> Anonymous
What about donwimals, now?
We still haven't answered that question!
>> Anonymous
It seems reasonable that downimals would exist. I mean, genetic mutations and all of that. But, given that nature kills them, and not an active effort of others of their kind, logic would dictate that we wouldn't be allowed to kill downies. Instead, we could let them survive on their own until they die.

Or, you know, be civilized and support each other and all of that. Or would you rather scavenge for food in the wild?
>> Anonymous
pretty nice expaination.
Still, does anyone positively know that downimals exist or has ever seen one?
>> Anonymous
Down syndrome is caused by a fairly specific genetic problem in humans, particularly trisomy of chromosome 21.

(In fact, Down Syndrome is often referred to as Trisomy 21.)

This means rather than two copies of chromosome 21, a down syndrome sufferer has three. This is caused by errors during the generation of sperm and egg cells in the parents' bodies.

While some retardation may be caused by trisomy or polysomy of other chromosomes, it's nowhere near so severe. Most people who have polysomy that's not Trisomy 21 are never diagnosed.

Accordingly, an animal needs a chromosome that's very similar to the Human 21 chromosome in order to have Down syndrome.

This *has* been observed in some animals, but certainly not all.

In particular, Mice can be born with Trisomy 14. Mouse 14 is roughly equivalent to Human 21. These 'Down' mice have symptoms that are almost identical to those in affected humans. In a lab environment, where these mice are studied for the sake of treating Down syndrome, the affected mice have little or no trouble surviving in a social environment and mating with non-affected mice.

One would assume that wild mice would have a much more difficult time due to lower intelligence and an environment much less tolerant of any kind of defect.
>> Anonymous
>>46516

Reading back over that, I need to clarify the 'nowhere no severe' part.

Serious genetic errors usually cause a human embryo or fetus to abort. They usually don't live long enough in the womb to have any diagnosis.

That small fraction who do have serious genetic errors, such as polysomy, and do manage to survive aren't usually diagnosed unless they obviously have Down Syndrome since the problems they encounter aren't nearly so severe as Down.
>> Anonymous
>>46487
"...the affected mice have little or no trouble surviving in a social environment and mating with non-affected mice."
This is indeed interesting, but seems highly unlikely to me.
Wouldn't there be a huge chance that their offspring had corrupted chromosomes as well?
Furthermore, compared to humans, people with down-syndrome have not a chance in terms of sexual selection, have they?
Is this becuase human-social behaviour and mating-behaviour is much more complex in terms of selection?
>> Anonymous
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>>46523

Mating is not necessarily the same thing as reproducing. Most creatures with serious genetic abnormalities are sterile.

However, it is sometimes possible for a human with Down Syndrome to mate and reproduce. It's even possible for them to have unaffected children.

http://www.greenjournal.org/cgi/content/abstract/59/6/13s

From the research:

>>A new case of pregnancy in a 29-year-old woman with trisomy 21 is described. She gave birth to a male infant, chromosomally and phenotypically normal, who died the day after delivery due to prematurity. Thirty pregnancies of 26 affected mothers, including the present woman, resulted in 10 children with Down syndrome, 18 children (1 set of twins) without Down syndrome, and 3 spontaneous abortions. Although rare, pregnancies in women with Down syndrome could become more frequent, increasing the importance of genetic, reproductive, and obstetric problems. These problems are reviewed with special reference to the occurrence of nonspecific abnormalities in chromosomally normal children, difficulties in labor and delivery, and frequency of prematurity and low birth weight.

TS16 Mice occur naturally, and have been bred in labs for research purposes.

http://dsresearch.stanford.edu/community/index2005q1.html
>> Anonymous
Boy, imagine your parents have the downs, that would suck!
>> Anonymous
Scientific discussion in my 4chan? GTFO!

Seriously, genetic science is fascinating, both for the the science and for the interesting moral issues it raises.

Those mice have been engineered to have human genes. They're obviously not humans, but share some human's genetic material.

Does that make the human gene donor one of their parents?

It's creepy, but if the person who donated the genes is okay with it, and it helps treat people with genetic problems, then it seems like a good solution.
>> sausage expert (eaten 356+ kinds of sausage, last: Schwarzwald bratwurst) !GOTHoQ9ES6
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>Downimals
?
>> Anonymous
>>46534

wouldn't the authorities take you away from them and give you to foster parents? I can't imagine downs parents could take care of a toddler.
>> Anonymous
actually, that tiger is a vampire. watch Buffy sometimes, you guys.
>> Anonymous
my friend has a ferret with downs.she told the vet and he said oh no thats not possible.but then he saw it,so i do think that some animals show some simptoms of it.
>> Anonymous
STFU ^ flat tiger is cute
>> Anonymous
>>46625
People with Downs syndrome are roughly 7 mental years behind people of the same age who have had the same level of education. However, this was not known until recently because people with Downs were often treated as 'lost causes' and no attempt was made to educate them of prepare them to lead self-sufficient lives. Basically, it isn't that they can't learn things, just that they learn things more slowly. It may be possible to attribute the behavioral disfunctions sometimes found in Downs patients to the immaturity consequent to having no expectations placed on them.
>> Anonymous
I find it more amusing to imagine that the tiger in the OP has Tourettes
>> Termination of Down'ed people Mr. Smith
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This subject of the termination of the "people with the downs" is currently being ponderated by the commitee of agents. For now, they are being hunted and disposed, but a massive disposal of them is inpossible right now, since the extermination of Mimes have priority.
Now go live your miserable lifes. Go. Shoo.