The Control Systems
Chapter
27
Outline
	27.1	Nervous System
	•	Both the nervous and endocrine systems use chemical signals as a means of communication.472
	•	The organizational division between the central and peripheral nervous systems is found in some invertebrates.473
	•	The nervous system has three functions: receive sensory input; integrate the input; send out motor commands.474
	•	The nerve impulse is self-propagating along an axon and results in the release of a neurotransmitter into a synaptic cleft.475
	•	Among vertebrates, it’s possible to trace an increase in the size and complexity of the cerebrum.478
	•	In the central nervous system, the cerebrum 
is organized to perform specific functions.478–79
	•	The peripheral nervous system includes the somatic system, which controls skeletal muscles, and the autonomic system, which regulates the activity of glands and cardiac and smooth muscle.480–82
	27.2	Endocrine System
	•	The endocrine system helps regulate the internal environment by affecting the metabolism of cells.483
	•	The hypothalamus controls the function of the pituitary gland, which in turn controls several other glands.484–85
	•	The thyroid and parathyroid glands regulate the blood calcium level; the adrenal medulla and adrenal cortex both respond to stress; and the pancreas secretes two hormones that regulate the blood glucose level.486–88
Obviously, the brain’s role in the human body is critical to survival. The brain controls nearly all the activities in the body, including those of the other organ systems. When particular areas of the brain malfunction, a multitude of problems, or even death, can occur. Certain conditions, such as epilepsy, inherited disease, or infection, can cause unusual electrical activity in areas of the brain, leading to severe and debilitating seizures. When the condition is serious enough and cannot be controlled by medication, physicians may consider performing a surgery termed a hemispherectomy. In this procedure, a portion of the brain (anywhere from a lobe up to a complete half) is completely removed. Unbelievably, many of the functions linked to the side of the brain that was removed can be “re-mapped” to the remaining side. In fact, most children who have undergone this procedure have experienced minimal lasting side effects, other than some minor paralysis on one side of the body. Learning ability does not seem to be significantly damaged by the procedure. Such drastic surgeries have taught us that the brain is a highly adaptable organ that can recover from significant trauma. 
Understanding the structure and function of the nervous system is of critical importance to understanding the functioning of other organs and organ systems in the body. In this chapter, you will learn how the central and peripheral nervous systems operate, as well as how the central nervous system communicates with the endocrine system, which in turn regulates the body’s internal environment. 
27.1		Nervous System
The nervous system and the endocrine system work together to regulate the activities of the other systems. Both control systems use chemical signals when they respond to changes that might threaten homeostasis, but they have different means of delivering these signals (Fig. 27.1). The nervous system quickly sends a message along a nerve fiber directly to a target organ, such as skeletal or smooth muscle. Once a chemical signal is released, the muscle brings about an appropriate response. 
The endocrine system uses the blood vessels of the cardiovascular system to send a hormone as a messenger to a target organ, such as the liver. The endocrine system is slower-acting because it takes time for the hormone to move through a vessel to a target organ. Also, hormones change the metabolism of cells, and this takes time; however, the response is longer-lasting. Cellular metabolism tends to remain the same for at least a limited period of time.
Let’s first turn our attention to the human nervous system. As we examine it, we will also compare it to the nervous systems of other animals. 
The Human Nervous System
The nervous system is always involved in an animal’s ability to move around. In fact, about the only function of the nervous system in some animals, such as planarians, is movement, particularly to feed. Planarians are predators, and the worm wraps itself around its prey, entangling it in slime and pinning it down. Then a muscular pharynx extends out the mouth, and by a sucking motion, the prey is torn up and swallowed. The bilateral symmetry of planarians is reflected in the organization of their nervous system. They have two lateral nerve cords (bundles of nerves) joined together by transverse nerves. The arrangement is called a ladderlike nervous system. A “brain” receives sensory information from the eyespots and sensory cells in the auricles. The two lateral nerve cords allow a rapid transfer of information from the cerebral ganglia to the posterior end, and the transverse nerves between the nerve cords keep the movement of the two sides coordinated. The nervous organization in planarians is a foreshadowing of the central and peripheral nervous systems that are found in more complex invertebrates, such as an earthworm, and in vertebrates, including humans (Fig. 27.2). 
In humans, the nervous system controls the muscular system and all the other systems. The central nervous system (CNS) -includes the brain and spinal cord, which have a central -location—they lie in the midline of the body. The peripheral nervous system (PNS) consists of nerves that lie outside the central nervous system. The brain gives off paired cranial nerves (one on each side of the body), and the spinal cord gives off paired spinal nerves. The division between the central nervous system and the peripheral nervous system is arbitrary; the two systems work together and are connected to one another.
What makes the human nervous system more complex than the planarian system? Five trends during the evolution of the vertebrate nervous system can be identified: 
	•	A CNS developed that is able to summarize incoming messages before ordering outgoing messages. 
	•	Nerve cells (neurons) became specialized to send messages to the central nervous system (CNS), between neurons in the CNS, or away from the CNS.
	•	A brain evolved that has special centers for receiving input from various regions of the body and for directing their activity.
	•	The CNS became connected to all parts of the body by peripheral nerves. Therefore, the central nervous system can respond to both external and internal stimuli. 
	•	Complex sense organs, such as the human eye and ear, arose that can detect changes in the external environment. 
This chapter discusses the first four aspects of the human nervous system. Sensory input and muscle response are the topics of Chapter 28.
Neurons
The shape of a nerve cell, or neuron, is suitable to its function. The cell body contains the nucleus and other organelles that allow a cell to function. The neuron’s many short dendrite nerve fibers fan out to receive signals from -sensory receptors or other neurons. These signals can result in nerve impulses carried by an axon. The axon, a nerve fiber that is typically longer than a dendrite, is the portion of a neuron that conducts nerve impulses. An axon can reach all the way from the end of your spinal cord to the tip of your big toe or from your big toe to the spinal cord, depending on which way messages are being conducted. Long axons are covered by a white myelin sheath formed from the membranes of tightly spiraled cells that leave gaps called neurofibril nodes (nodes of Ranvier). Myelin sheaths account for our impression that nerves are white and glistening. 
The nervous system has three types of neurons specific to its three functions (Fig. 27.3): 
	1.	The nervous system -receives sensory input. Sensory neurons perform this function. They take nerve impulses from sensory receptors to the CNS. The sensory receptor, which is the distal end of the axon of a sensory neuron, may be as simple as a naked nerve ending (a pain receptor), or may be built into a highly complex organ, such as the eye or ear. In any case, the axon of a sensory neuron can be quite long if the sensory receptor is far from the CNS. 
	2.	The nervous system performs integration—in other words, the CNS sums up the -input it receives from all over the body. Interneurons occur entirely within the CNS and take nerve impulses between various parts of the CNS. Some interneurons lie between sensory neurons and motor neurons, and some take messages from one side of the spinal cord to the other or from the brain to the spinal cord, and vice versa. They also form complex pathways in the brain where processes that account for thinking, memory, and language occur.
	3.	The nervous system generates motor output. Motor neurons take nerve impulses from the CNS to muscles or glands. Motor neurons cause muscle fibers to contract or glands to secrete, and therefore they are said to innervate these -structures.
The Nerve Impulse
Like some other cellular processes, the nerve impulse is also dependent on concentration gradients. In neurons, these concentration gradients are maintained by the sodium-potassium pump. This pump actively transports sodium ions (Na1) to the outside of the axon and actively transports potassium ions (K1) inside. Aside from ion concentration differences across the axon’s membrane, a charge difference also exists. The inside of an axon is negative compared to the outside. This charge difference is due in part to an unequal distribution of ions across the membrane, but is also due to the presence of large, negatively charged proteins in the axon cytoplasm. 
The charge difference across the axon’s membrane offers a potential for change, or an action potential, as the nerve impulse is also called. The nerve impulse is a rapid, short-lived, self-propagating reversal in the charge difference across the axon’s membrane. Figure 27.4 shows how it works. A nerve impulse involves two types of gated channel proteins in the axon’s membrane: One allows sodium (Na1) to pass through the membrane, and the other allows potassium (K1) to pass through the membrane. As an axon is conducting a nerve impulse, the Na1 gates open at a particular location, and the inside of the axon becomes positive as Na1 moves from outside the axon to the inside. The Na1 gates close, and then the K1 gates open. Now K1 moves from inside the axon to outside the axon, and the charge reverses back again. 
In Figure 27.4, the axon is unmyelinated, and the action potential at one locale stimulates an adjacent part of the axon’s membrane to produce an action potential. In myelinated axons, an action potential at one neurofibril node causes an action potential at the next node (Fig. 27.5). This type of conduction, called saltatory -conduction, is much faster than otherwise. In thin, unmyelinated axons, the nerve impulse travels about 1.0 m/second, and in thick, myelinated -axons, the rate is more than 100 m/second. In any case, action potentials are self-propagating; each action potential generates another along the length of an axon.
The conduction of a nerve impulse (action potential) is an all-or-none event—that is, either an axon conducts a nerve impulse or it does not. The intensity of a message is -determined by how many nerve impulses are generated within a given time span. An axon can conduct a volley of nerve -impulses because only a small number of ions are -exchanged with each impulse. As soon as an impulse has passed by each successive portion of an axon, it undergoes a short -refractory period during which it is unable to conduct an impulse. During a refractory period, the sodium gates -cannot yet open. This period ensures that nerve impulses travel in only one direction and do not reverse.
The Synapse
Each axon has many axon terminals (Fig. 27.6). In the CNS, a terminal lies very close to the dendrite (or the cell body) of another neuron. This region of close proximity is called a synapse. In the PNS, when a terminal is close to a muscle cell, the region is called a neuromuscular junction. A small gap exists at a synapse, and this gap is called the synaptic cleft. How is it possible to excite the next neuron or a muscle cell across this gap? Transmission across a synaptic cleft is carried out by chemical signals called neurotransmitters, which are stored in synaptic vesicles. When nerve impulses traveling along an axon reach an axon terminal, synaptic vesicles release a neurotransmitter into the synaptic cleft. Neurotransmitter molecules diffuse across the cleft and bind to a specific -receptor protein on the receiving neuron or other target cell.
Depending on the type of neurotransmitter and/or the type of receptor, the response of the receiving neuron or muscle cell can be toward excitation or toward inhibition. At least 25 different neuro-transmitters have been identified, but two very well-known neuro-transmitters are acetylcholine (ACh) and norepinephrine (NE).
Once a neurotransmitter has been released into a synaptic cleft and has initiated a response, the neurotransmitter is removed from the cleft. In some synapses, the receiving neuron contains enzymes that rapidly inactivate the neurotransmitter. For example, the enzyme acetylcholinesterase (AChE) breaks down acetylcholine. In other synapses, the original neuron rapidly reabsorbs the neurotransmitter. For example, norephinephrine is reabsorbed by the axon terminal. The short existence of neurotransmitters at a synapse prevents continuous stimulation (or -inhibition) of the receiving neuron.
A single neuron has many dendrites plus the cell body, and both can have synapses with many other neurons. One thousand to ten thousand synapses per single neuron are not uncommon. Therefore, a neuron is on the receiving end of many signals. An excitatory neurotransmitter produces a potential change that drives the neuron closer to an action potential, and an inhibitory neurotransmitter produces a potential change that drives the neuron further from an action potential. Neurons integrate these incoming signals. Integration is the summing up of excitatory and inhibitory signals. If a neuron receives many excitatory signals (either at different synapses or at a rapid rate from one synapse), chances are the axon will transmit a nerve impulse. On the other hand, if a neuron receives both inhibitory and excitatory signals, the summing up of these signals may prohibit the axon from firing.
Drug Abuse
Many drugs that affect the nervous system act by interfering with or promoting the action of neurotransmitters. A drug can either enhance or block the release of a neurotransmitter, mimic the action of a neurotransmitter or block the receptor for it, or interfere with the removal of a neurotransmitter from a synaptic cleft. Stimulants are drugs that increase the likelihood of neuron excitation, and depressants decrease the likelihood of excitation. Increasingly, researchers believe that dopamine, a neurotransmitter in the brain, is responsible for mood. Many of the new medications developed to counter drug dependence and mental illness affect the release, reception, or breakdown of dopamine.
Drug abuse is apparent when a person takes a drug at a dose level and under circumstances that increase the potential for a harmful effect. A drug abuser often takes more of the drug than was intended. Drug abusers are apt to display a psychological and/or physical dependence on the drug. With physical dependence, formerly called “addiction,” more of the drug is needed to get the same effect, and withdrawal symptoms occur when the user stops taking the drug.
Cocaine
Cocaine is an alkaloid derived from the shrub Erythroxylon coca. It is sold in powder form and as crack, a more potent extract. Because cocaine prevents the synaptic uptake of dopamine, the user experiences a “rush” sensation. The epinephrine-like effects of dopamine account for the state of arousal that lasts for several minutes after the rush experience.
A cocaine binge can go on for days, after which the individual suffers a crash. During the binge -period, the user is hyperactive and has little desire for food or sleep but has an increased sex drive. During the crash period, the user is fatigued, depressed, and irritable, has memory and concentration problems, and displays no interest in sex. 
Cocaine causes extreme physical dependence. With continued cocaine use, the body begins to make less dopamine to compensate for a seemingly excess supply. The user, therefore, experiences physical dependence withdrawal symptoms, and an intense craving for cocaine. These are indications that the person is highly dependent upon the drug.
Overdosing on cocaine can cause seizures and cardiac and respiratory arrest. It is possible that long-term cocaine abuse causes brain damage (Fig. 27.7). Babies born to addicts suffer withdrawal symptoms and may have neurological and developmental problems.
Heroin
Heroin is derived from morphine, an alkaloid of opium. Once heroin is injected into a vein (Fig. 27.8), a feeling of euphoria, along with relief of any pain, occurs within 3 to 6 minutes. Side effects can include nausea, vomiting, restlessness, anxiety, mood disorders, and respiratory and circulatory depression. Heroin binds to receptors meant for the endorphins, special neurotransmitters that kill pain and produce a feeling of tranquility. With time, the body’s production of endorphins decreases. Physical dependence develops, and the euphoria originally experienced upon injection is no longer felt. Heroin withdrawal symptoms are quite severe, and infants born to women who are physically dependent also experience these withdrawal symptoms.
Marijuana
The dried flowering tops, leaves, and stems of the Indian hemp plant Cannabis sativa contain and are covered by a resin that is rich in THC (tetrahydrocannabinol). The names cannabis and marijuana apply to either the plant or THC. Usually, marijuana is smoked in a cigarette form called a “joint.” 
Recently, researchers have found that marijuana binds to a receptor for anandamide, a neurotransmitter that seems to create a feeling of peaceful contentment. The occasional marijuana user experiences a mild euphoria along with alterations in vision and judgment, which result in distortions of space and time. Motor incoordination, including the inability to speak coherently, takes place. Heavy use can result in hallucinations, anxiety, depression, rapid flow of ideas, body image distortions, paranoid reactions, and similar psychotic symptoms. Craving and difficulty in stopping usage can occur as a result of regular use.
The Central Nervous System
The organization of the brains in certain vertebrates—namely, reptiles, birds, and mammals (horse and human)—is compared in Figure 27.9a. If we divide the brain into a hindbrain, midbrain, and forebrain, we can see that the forebrain is most prominent in humans. The forebrain of mammals also has an altered function in that it becomes the last depository for sensory information. This change accounts for why the forebrain carries on much of the integration for the entire nervous system before it sends out motor instructions to glands and muscles. In humans, the spinal cord provides a means of communication between the brain and the spinal nerves, which are a part of the PNS. (Spinal nerves leave the spinal cord and take messages to and from the skin, glands, and muscles in all areas of the body, except for the head and face.) Myelin-ated long fibers of interneurons in the spinal cord run -together in bundles called tracts. These tracts connect the spinal cord to the brain. -Because the tracts cross over at one point, the left side of the brain -controls the right side of the body, and vice versa. Also, as discussed on page 481, the spinal cord is involved in reflex actions, which are programmed, built-in circuits that allow for protection and survival. They are present at birth and require no conscious thought to take place.
The Brain
Our discussion will center on these parts of the brain: the cerebrum, the diencephalon, the cerebellum, and the brain stem (Fig. 27.9b). 
CerebrumThe cerebrum communicates with and coordinates the activities of the other parts of the brain. The cerebrum has two halves, and each half has a number of lobes, which are color coded in Figure 27.10. Most of the cerebrum is white matter where the long axons of interneurons are taking nerve impulses to and from the cerebrum. The highly convoluted outer layer of gray matter that covers the cerebrum is called the cerebral cortex. The cerebral cortex contains over one billion cell bodies, and it is the region of the cerebrum that accounts for sensation, voluntary movement, and higher thought processes. 
Investigators have found that each part of the cerebrum has specific functions. To take an example, the primary sensory area located in the parietal lobe receives information from the skin, skeletal muscles, and joints. Each part of the body has its own particular receiving area. The primary motor area, on the other hand, is in the frontal lobe just before the small cleft that divides the frontal lobe from the parietal lobe. Voluntary commands to skeletal muscles involve the primary motor area, and the muscles in each part of the body are controlled by a certain section of the primary motor area. 
The lobes of the cerebral cortex have a number of specialized centers to receive information from the sensory receptors for sight, hearing, and smell. The lobes also have association areas where integration occurs. The -prefrontal area, an association area in the frontal lobe, -receives information from the other association areas and uses this information to reason and plan our actions. Integration in this area accounts for our most cherished human abilities to think critically and to formulate appropriate -behaviors.
DiencephalonBeneath the cerebrum is the diencephalon, which contains the hypothalamus and the thalamus (see Fig. 27.9b). The -hypothalamus is an integrating center that helps maintain homeostasis by -regulating hunger, sleep, thirst, body temperature, and -water balance. The hypothalamus controls the pituitary gland, and thereby serves as a link between the nervous and endocrine systems. The thalamus is on the receiving end for all sensory input except smell. Information from the eyes, ears, and skin -arrives at the thalamus via the cranial nerves and tracts from the spinal cord. The thalamus integrates this information and sends it on to the appropriate portions of the cerebrum. The thalamus is involved in arousal of the cerebrum, and it also participates in higher mental functions such as memory and emotions.
The pineal gland, which secretes the hormone melatonin, is located in the diencephalon. Presently, there is much popular interest in melatonin because it is released at night when we are sleeping. Some researchers believe it can be used to help prevent jet lag or insomnia. 
CerebellumThe cerebellum has two portions that are joined by a narrow median strap. Each portion is pri-mar-ily composed of white matter, which in longitudinal section has a treelike pattern (see Fig. 27.9b). Overlying the white matter is a thin layer of gray matter that forms a series of complex folds.
The cerebellum receives sensory input from the eyes, ears, joints, and skeletal muscles about the present position of body parts, and it also receives motor output from the cerebral cortex about where these parts should be located. After integrating this information, the cerebellum sends motor -impulses by way of the brain stem to the skeletal muscles. In this way, the cerebellum maintains posture and balance. It also ensures that all of the muscles work together to produce smooth, coordinated voluntary movements. The cerebellum assists the learning of new motor skills such as playing the piano or hitting a baseball.
Brain StemThe brain stem, which contains the midbrain, the pons, and the medulla oblongata, connects the rest of the brain to the spinal cord (see Fig. 27.9b). It contains tracts that ascend or descend between the spinal cord and higher brain centers. The medulla oblongata contains a number of reflex centers for regulating heartbeat, breathing, and vasoconstriction (blood pressure). It also contains the reflex centers for vomiting, coughing, sneezing, hiccuping, and -swallowing. In addition, the medulla oblongata helps control various internal organs. 
The Limbic System
The limbic system is a complex network that includes the diencephalon and areas of the cerebrum (Fig. 27.11). The limbic system blends higher mental functions and primitive emotions into a united whole. It accounts for why activities such as sexual behavior and eating seem pleasurable and also why, say, mental stress can cause high blood pressure.
Two significant structures within the limbic system are the hippocampus and the amygdala, which are essential for learning and memory. The hippocampus, a seahorse-shaped structure that lies deep in the temporal lobe, is well situated in the brain to make the prefrontal area aware of past experiences stored in sensory association areas. The amygdala, in particular, can cause these experiences to have emotional overtones. A connection between the frontal lobe and the limbic -system means that reason can keep us from acting out strong feelings.
Learning and MemoryMemory is the ability to hold a thought in mind or recall events from the past, ranging from a word we learned only yesterday to an early emotional experience that has shaped our lives. Learning takes place when we retain and utilize past memories.
The prefrontal area in the frontal lobe is active during short-term memory, as when we temporarily recall a telephone number. Some telephone numbers go into long-term memory. Think of a telephone number you know by heart, and see if you can bring it to mind without also thinking about the place or person associated with that number. Most likely you cannot, because typically long-term memory is a mixture of what is called semantic memory (numbers, words, and so on) and episodic memory (persons, events, and other associations). Skill memory is a type of memory that can exist independent of episodic memory. Skill memory is what allows us to -perform motor activities like riding a bike or playing ice hockey. A person who has Alzheimer disease (AD) experiences a progressive loss of memory, particularly for recent events. Gradually the person loses the ability to perform any type of daily activity and becomes bedridden. In AD patients, abnormal neurons occur, especially in the hippocampus and amygdala. Major research efforts are devoted to seeking a cure for AD. 
What parts of the brain are functioning when we -remember something from long ago? Our long-term memories are stored in bits and pieces throughout the sensory association areas of the cerebral -cortex. The hippocampus gathers this information together for use by the prefrontal area of the frontal lobe when we remember Uncle George or our summer holiday. Why are some memories so emotionally charged? The amygdala is responsible for fear conditioning and for associating danger with sensory information received from the thalamus and the cortical -sensory areas.
The Peripheral Nervous System
The peripheral nervous system (PNS) lies outside the central nervous system and contains nerves, which are bundles of axons (Fig. 27.12). The cell bodies of neurons are found in the CNS—that is, the brain and spinal cord—or in ganglia. Ganglia (sing., -ganglion) are collections of cell bodies within the PNS.
Humans have 12 pairs of cranial nerves attached to the brain. Cranial nerves are largely concerned with the head, neck, and facial regions of the body. However, the vagus nerve is a cranial nerve that has branches not only to the pharynx and larynx, but also to most of the internal organs.
Humans have 31 pairs of spinal nerves, and each contains many sensory and motor axons. The dorsal root of a spinal nerve contains the axons of sensory neurons, which conduct impulses to the spinal cord from sensory receptors. The cell body of a sensory neuron is in the dorsal root ganglion. The ventral root contains the axons of motor neurons, which conduct impulses away from the cord, largely to skeletal muscles (Fig. 27.13). Each spinal nerve serves the particular region of the body in which it is located.
The Somatic System
The somatic system of the PNS includes the nerves that take sensory -information from external sensory receptors to the CNS and motor commands away from the CNS to skeletal muscles. Voluntary control of skeletal muscles always originates in the brain. Involuntary responses to stimuli, called reflexes, can involve either the brain or just the spinal cord. Flying -objects cause our eyes to blink, and sharp pins cause our hands to jerk away even without our having to think about it.
Figure 27.13 illustrates the path of a reflex that involves only the spinal cord. If your hand touches a sharp pin, sensory -receptors in the skin generate nerve impulses that move along sensory axons toward the spinal cord. Sensory neurons that enter the spinal cord pass signals on to many interneurons. Some of these interneurons synapse with motor neurons. The short dendrites and the cell bodies of motor neurons are in the spinal cord, but their axons leave the cord. Nerve impulses travel along motor axons to an effector, which brings about a response to the stimulus. In this case, a muscle contracts so that you withdraw your hand from the pin. Various other reactions are possible—you will most likely look at the pin, wince, and cry out in pain. This whole series of responses is explained by the fact that some of the interneurons involved carry nerve impulses to the brain. Also, sense organs send messages to the brain that make us aware of our actions. The brain makes you aware of the stimulus and directs these other reactions to it.
The Autonomic System
The autonomic system of the PNS automatically and involuntarily regulates the activity of glands and cardiac and smooth muscle. The system is divided into the parasympathetic and sympathetic divisions (Fig. 27.14). Reflex actions, such as those that regulate blood pressure and breathing rate, are especially important to the maintenance of homeostasis. These reflexes begin when the sensory neurons in contact with internal organs send information to the CNS. They are completed by motor neurons within the autonomic system.
The parasympathetic division includes a few cranial nerves (e.g., the vagus nerve) and also axons that arise from the last portion of the spinal cord. The parasympathetic division, sometimes called the “housekeeper division,” promotes all the internal responses we associate with a relaxed state (see photograph). For example, it causes the pupil of the eye to contract, promotes digestion of food, and retards the heartbeat. The neurotransmitter utilized by the parasympathetic division is acetylcholine (ACh).
Axons of the sympathetic division arise from portions of the spinal cord. The sympathetic division is especially important during emergency situations and is associated with “fight or flight.” If you need to fend off a foe or flee from danger, -active -muscles require a ready supply of glucose and oxygen. On the one hand, the sympathetic division accelerates the heartbeat and -dilates the bronchi. On the other hand, the sympathetic division inhibits the digestive tract, since digestion is not an -immediate -necessity if you are under attack. The sympathetic nervous system utilizes the neurotransmitter norepinephrine, which has a structure like that of epinephrine (adrenaline) released by the adrenal medulla. 
27.2		Endocrine System
The endocrine system consists of glands and tissues that -secrete chemical signals we call hormones (Fig. 27.15). Endocrine glands do not have ducts; they secrete their hormones directly into the bloodstream for distribution throughout the body. They can be contrasted with exo-crine glands, which have ducts and secrete their products into these ducts for transport to body cavities. For example, the salivary glands send saliva into the mouth by way of the salivary ducts.
The endocrine system and the nervous system are intimately involved in homeostasis, the relative stability of the internal environment. Several hormones directly affect the blood glucose, calcium, and sodium levels. Other hormones are involved in the maturation and function of the reproductive organs, and these are discussed in Chapter 29.
The Action of Hormones
The cells that can respond to a hormone have receptor proteins that bind to the hormone. Hormones cause these cells to undergo a metabolic change. The type of change is dependent on the chemical structure of the hormone. Steroid hormones (see Fig. 3.15, p. 37) are lipids, and they can pass through the plasma membrane. The hormone-receptor complex then binds to DNA, and gene expression follows—for example, a protein such as an enzyme is made by the cell. The enzyme goes on to speed a reaction in the cell (Fig. 27.16a). 
Peptide hormones is a category that includes peptides, proteins, glycoproteins, and modified amino acids. Peptide hormones can’t pass through the plasma membrane so they bind to a receptor protein in the plasma membrane. The peptide hormone is called the “first messenger” because a signal transduction pathway leads to a second molecule, i.e., the “second messenger,” that changes the metabolism of the cell. The second messenger sets in motion an enzyme pathway that is sometimes called an enzyme cascade because each enzyme in turn activates another. Because enzymes work over and over, every step in an enzyme cascade leads to more reactions—the binding of a single peptide hormone molecule can result in as much as a thousandfold response.
Hypothalamus and Pituitary Gland
The hypothalamus, a part of the brain (see Fig. 27.9), helps regulate the internal environment. For example, it is on the receiving end of information about the heartbeat and body temperature. And to correct any abnormalities, the hypothalamus communicates with the medulla oblongata, where the brain centers that control the autonomic system are located. The hypothalamus is also a part of the endocrine system. It controls the glandular secretions of the pituitary gland, a small gland connected to the brain by a stalklike structure. The pituitary has two portions, the anterior pituitary and the posterior pituitary, which are distinct from each other.  
Anterior Pituitary 
The hypothalamus controls the anterior pituitary by producing releasing hormones, most of which are stimulatory. The anterior pituitary in turn stimulates other glands: 
	1.	Thyroid--stimulating hormone (TSH) stimulates the thyroid to produce  triiodothyronine (T3) and thyroxine (T4). 
	2.	Adrenocorticotropic hormone (ACTH) stimulates the adrenal cortex to produce the glucocorticoids. 
	3.	Gonadotropic hormones (FSH and LH) stimulate the gonads—the testes in males and the ovaries in females—to produce gametes and sex hormones. 
In these instances, a three-tiered control system develops that is described in Figure 27.17. For example, the secretion of thyroid-releasing hormone (TRH) by the hypothalamus stimulates the thyroid to produce the thyroid-stimulating hormone (TSH), and the thyroid produces its hormones (T3 and T4), which feed back to inhibit the release of the first two hormones mentioned.
Two other hormones produced by the anterior -pituitary do not affect other endocrine glands (Fig. 27.18). Prolactin (PRL) is produced in quantity during pregnancy and after childbirth. It causes the mammary glands in the breasts to develop and produce milk. It also plays a role in carbohydrate and fat metabolism. Growth hormone (GH) promotes skeletal and muscular growth. It stimulates the rate at which amino acids enter cells and protein synthesis occurs. Underproduction of growth hormone leads to pituitary dwarfism, and overproduction can lead to pituitary giantism. 
Posterior Pituitary
The hypothalamus produces two hormones, antidiuretic hormone (ADH) and oxytocin (Fig. 27.18). These hormones pass through axons into the posterior pituitary, where they are stored in axon terminals. When the hypothalamus determines that the blood is too concentrated, ADH is released from the posterior pituitary. Upon reaching the kidneys, ADH causes water to be reabsorbed. As the blood becomes -dilute, ADH is no longer released. This is also an example of control by negative feedback because the effect of the hormone (to dilute blood) acts to shut down the release of the hormone. Negative feedback, as discussed in Chapter 22, maintains homeostasis.
Oxytocin, the other hormone made in the hypothalamus, causes uterine contraction during childbirth and milk letdown when a baby is nursing. 
Thyroid and Parathyroid Glands
The thyroid gland is a large gland located in the neck that produces two hormones: Triiodothyronine (T3) contains three iodine atoms, and thyroxine (T4) contains four iodine atoms. To produce these hormones, the thyroid gland needs iodine. The concentration of iodine in the thyroid gland can increase to as much as 25 times that of the blood. If iodine is lacking in the diet, the thyroid gland is unable to produce the thyroid hormones. In response to constant stimulation by the anterior pituitary, the thyroid enlarges, resulting in a simple goiter (Fig. 27.19). Some years ago, it was discovered that the use of iodized salt (table salt to which iodine has been added) helps prevent simple goiter.
Thyroid hormones increase the metabolic rate. They do not have a target organ; instead, they stimulate all the cells of the body to metabolize at a faster rate. More glucose is broken down, and more energy is utilized.
In the case of hyperthyroidism (oversecretion of thyroid hormone), or Graves disease, the thyroid gland is overactive, and a goiter forms. This type of goiter is called exophthalmic goiter (Fig. 27.20). The eyes protrude because of swelling in eye socket tissues and in the muscles that move the eyes. The patient usually becomes hyperactive, nervous, and irritable, and suffers from insomnia. Removal or destruction of a portion of the thyroid by means of radioactive iodine is sometimes effective in curing the condition. 
Calcium Regulation
The thyroid gland also produces calcitonin, a hormone that helps regulate the blood calcium level. Calcium (Ca21) plays a significant role in both nervous conduction and muscle contraction. It is also necessary for blood clotting. Calcitonin temporarily reduces the activity and number of osteoclasts, a type of cell that breaks down bone. Therefore, more calcium is deposited in bone. When the blood calcium lowers to normal, the release of calcitonin by the thyroid is inhibited by negative feedback, but a low level stimulates the release of parathyroid hormone (PTH) by the parathyroid glands. The parathyroid glands are embedded in the posterior surface of the thyroid gland. Many years ago, the four parathyroid glands were sometimes mistakenly removed during thyroid surgery because of their size and location. 
 Parathyroid hormone promotes the activity of osteoclasts and the release of calcium from the bones. PTH also promotes the reabsorption of calcium by the kidneys, where it activates vitamin D. Vitamin D, in turn, stimulates the absorption of calcium from the intestine. These effects bring the blood calcium level back to the normal range so that the parathyroid glands no longer secrete PTH.
When insufficient parathyroid hormone production leads to a dramatic drop in the blood calcium level, tetany results. In tetany, the body shakes from continuous muscle contraction. This -effect is brought about by increased -excitability of the nerves, which initiate nerve impulses spontaneously and with-out rest. 
Adrenal Glands
Two adrenal glands sit atop the kidneys. Each adrenal gland consists of an inner portion called the adrenal medulla and an outer portion called the adrenal cortex. These portions, like the anterior pituitary and the posterior pituitary, have no structural connection with one another.
The hypothalamus exerts control over the activity of both portions of the adrenal glands. It initiates nerve impulses that travel by way of the brain stem, spinal cord, and sympathetic nerve fibers to the adrenal medulla, which then secretes its hormones. The hypothalamus, by means of ACTH-releasing hormone, controls the anterior pituitary’s secretion of ACTH, which in turn stimulates the adrenal cortex. Stress of all types, including both emotional and physical trauma, prompts the hypothalamus to stimulate both the adrenal medulla and the adrenal cortex.
Adrenal Medulla
Epinephrine (adrenaline) and norepinephrine (nor-adrenaline) produced by the adrenal medulla rapidly bring about all the body changes that occur when an individual reacts to an emergency situation. The effects of these -hormones are short-term. In contrast, the hormones produced by the adrenal cortex provide a long-term response to stress.
Adrenal Cortex
The two major types of hormones produced by the adrenal cortex are the mineralocorticoids, such as aldosterone, and the glucocorticoids, such as cortisol. Aldosterone acts on the kidneys and thereby regulates salt and water balance, leading to increases in blood volume and blood pressure. Cortisol regulates carbohydrate, protein, and fat metabolism, leading to an increase in the blood glucose level. It is also an antiinflammatory agent. The adrenal cortex also secretes a small amount of both male and female sex hormones in both sexes.
When the level of adrenal cortex hormones is low due to hypo-secretion, a person develops Addison disease. ACTH may build up as more is secreted to attempt to stimulate the adrenal cortex. The excess can cause bronzing of the skin because ACTH in excess stimulates melanin production. Without cortisol, glucose cannot be replenished when a stressful situation arises. Even a mild infection can lead to death. The lack of aldosterone results in the loss of sodium and water by the kidneys and the development of low blood pressure, and possibly severe dehydration. Left untreated, Addison disease can be fatal.
When the level of adrenal cortex hormones is high due to hypersecretion, a person develops Cushing syndrome (Fig. 27.21). The excess cortisol results in a tendency toward diabetes mellitus as muscle protein is metabolized and -subcutaneous fat is deposited in the midsection. The trunk is obese, while the arms and legs remain a normal size. An excess of aldosterone and reabsorption of sodium and water by the kidneys lead to a basic blood pH and hypertension. The face swells and takes on a moon shape. Masculinization may occur in women because of excess adrenal male sex hormones.
Pancreas
The pancreas is composed of two types of tissue. Exo-crine tissue produces and secretes digestive juices that pass through ducts to the small intestine. Endocrine tissue, called the pancreatic islets (islets of Langerhans), produces and secretes the hormones insulin and glucagon directly into the blood (Fig. 27.22).
Insulin is secreted when there is a high blood glucose level, which usually occurs just after eating. Insulin stimulates the uptake of glucose by cells, especially liver cells, muscle cells, and adipose tissue cells. In liver and muscle cells, glucose is then stored as glycogen. In muscle cells, glucose supplies energy for ATP production leading to protein metabolism and muscle contraction. In fat cells the breakdown of glucose supplies -glycerol and acetyl groups for the formation of fat. In these ways, insulin lowers the blood glucose level.
Glucagon is usually secreted -between meals, when the blood glucose level is low. The major target tissues of glucagon are the liver and adipose tissue. Glucagon stimulates the liver to break down glycogen to glucose and to use fat and protein in preference to glucose as energy sources. The latter spares glucose and makes more available to enter the blood. In these ways, glucagon raises the blood glucose level.
Diabetes Mellitus
Diabetes mellitus is a fairly common hormonal disease in which liver cells, and indeed all body cells, do not take up and/or metabolize glucose. Therefore, the cells are in need of glucose even though there is plenty in the blood. As the blood glucose level rises, glucose, along with water, is excreted in the urine. The loss of water in this way causes the diabetic person to be extremely thirsty. 
Two types of diabetes mellitus have been distinguished. In diabetes type 1 -(insulin-dependent diabetes), the pancreas is not producing insulin. The condition is believed to be brought on by exposure to an environmental agent, most likely a virus, whose presence causes cytotoxic T cells to destroy the pancreatic islets. The cells turn to the breakdown of protein and fat for energy. The metabolism of fat leads to acidosis (acid blood) that can eventually cause coma and death. As a result, the individual must have daily insulin injections. These injections control the diabetic symptoms but can still cause inconveniences, since either taking too much insulin or failing to eat regularly can bring on the symptoms of hypoglycemia (low blood sugar). These symptoms include perspiration, pale skin, shallow breathing, and anxiety. Because the brain requires a constant supply of glucose, unconsciousness can result. The treatment is quite simple: -Immediate ingestion of a sugar cube or fruit juice can very quickly counteract -hypoglycemia.
Of the 16 million people who now have diabetes in the United States, most have diabetes type 2 (noninsulin-dependent diabetes). This type of diabetes mellitus usually occurs in people of any age who are obese and inactive, as discussed in Chapter 25. The pancreas produces insulin, but the liver and muscle cells do not respond to it in the usual manner. They are said to be insulin resistant. If diabetes type 2 is untreated, the results can be as serious as those of type 1. Diabetics are prone to blindness, kidney disease, and circulatory disorders. It is usually possible to prevent or at least control diabetes type 2 by adhering to a low-fat and low-sugar diet and exercising regularly.
The Chapter in Review
Summary
27.1		Nervous System
Both the nervous and endocrine systems utilize chemical signals. The nervous system is organized into a central nervous system (CNS) and a peripheral nervous system (PNS).
Neurons
	•	Are composed of a cell body, an axon, and dendrites. Only axons conduct nerve impulses.
	•	Exist as three types: sensory (takes nerve impulses to the CNS), interneuron (takes nerve impulses between neurons of the CNS), and motor (takes nerve impulses away from the CNS).
The Nerve Impulse
	•	The sodium-potassium pump transports Na1 ions out of the axon and K1 ions into the axon. The inside of the axon has a negative charge; the outside has a positive charge.
	•	The nerve impulse is an action potential—there is a reversal of charge as Na1 ions flow in, and then a return to the previous charge difference as K1 flows out of an axon.
	•	The nerve impulse is much faster in myelinated axons because the impulse jumps from neurofibril node to neurofibril node.
The Synapse
	•	The synapse is a region of close proximity between an axon terminal and the next neuron (CNS), or between an axon terminal and a muscle cell (PNS).
	•	A nerve impulse causes the release of a neurotransmitter (can be excitatory or inhibitory) into the synaptic cleft.
	•	Neurotransmitters are ordinarily removed quickly from the synaptic cleft. AChE breaks down acetylcholine, for example.
	•	Drugs affect the action of neurotransmitters.
Central Nervous System
Brain
	•	The cerebrum functions in sensation, reasoning, learning and memory, language, and speech. The cerebral cortex has a primary sensory area in the parietal lobe that receives sensory information from each part of the body and a primary motor area in the frontal lobe that sends out motor commands to skeletal muscles. Association areas carry on integration. 
	•	In the diencephalon, the hypothalamus helps control homeostasis; the thalamus specializes in sending sensory input on to the cerebrum.
	•	The cerebellum primarily coordinates skeletal muscle contractions.
	•	In the brain stem, the medulla oblongata has centers for vital functions, such as breathing and the heartbeat, and helps control the internal organs.
Limbic System
The limbic system blends higher functions into a united whole. The hippocampus and amygdala have roles in learning and memory and appear to be affected in Alzheimer disease.
Peripheral Nervous System
	•	Somatic system:Reflexes (automatic responses) involve a sensory receptor, sensory neuron, interneurons in the spinal cord, and a motor neuron.
	• 	Autonomic system:The sympathetic division is active during times of stress, and the parasympathetic division is active during times of relaxation. Both divisions control the same internal organs.
27.2		Endocrine System
Endocrine glands secrete hormones into the bloodstream for distribution to target organs or tissues. Hormones are either steroids 
or peptides.
Hypothalamus and Pituitary Gland 
Hypothalamus secretes
releasing and inhibiting hormones	control anterior pituitary
antidiuretic hormone (ADH)	released by posterior pituitary;
	
causes water uptake by kidneys
oxytocin	released by posterior pituitary;
	
causes uterine contractions
Anterior Pituitary secretes
gonadotropic hormones (FSH and LH)	stimulate gonads
thyroid stimulating (TSH)	stimulates thyroid
adrenocorticotropic hormone (ACTH)	stimulates adrenal cortex
prolactin	causes milk production
growth hormone (GH) 	causes cell division, protein
	
synthesis, bone growth; too little = pituitary dwarfism; too much = pituitary giantism
Thyroid Gland and Parathyroid Glands
Thyroid Gland secretes
thyroxine (T4) and 	increases metabolic rate;
triiodothyronine (T3)	
simple goiter when iodine is lacking, exopthalmic goiter when overactive
calcitonin	lowers blood calcium level
Parathyroid Glands secrete
parathyroid hormone (PTH) 	raises blood calcium level 
Adrenal Glands
Adrenal Medulla secretes
epinephrine and norepinephrine	response to emergency 
	
situations
Adrenal Cortex secretes
mineralocorticoids	causes kidneys to reabsorb Na;
(aldosterone)	
too little as in Addison disease  = low blood pressure; too much as in Cushing syndrome = high blood pressure
glucocorticoids	raises blood glucose level; too 
(cortisol)	
little as in Addison disease = body can’t respond to stress; too much as in Cushing syndrome = diabetes
sex hormones	male/female differences
Pancreas secretes
insulin	causes cells to take up and liver
	
to store glucose as glycogen; too little = diabetes mellitus
glucagon	causes liver to break down glycogen
Thinking Scientifically
	1.	Recent research indicates that Parkinson disease damages the sympathetic division of the peripheral nervous system. One test for sympathetic division function, called the Valsalva maneuver, requires the patient to blow against resistance. A functional nervous system will compensate for the decrease in blood output from the heart by constricting blood vessels. How do you suppose Parkinson patients respond to the Valsalva maneuver? How does this relate to a common condition in Parkinson patients, called orthostatic hypotension, in which blood pressure falls suddenly when the person stands up, leading to dizziness and fainting?
	2.	Researchers have been trying to determine the reason for a dramatic rise in diabetes type 2 in recent decades. A sedentary lifestyle and poor eating habits certainly contribute to the risk for developing the disease. In addition, however, some researchers have observed a connection between childhood vaccination and diabetes type 1. Epidemiological data from countries that have recently initiated mass immunization programs indicate that the incidence of diabetes type 1 has increased there as well. What might be the connection between vaccination and diabetes?
Testing Yourself
Choose the best answer for each question.
	1.	Unlike the nervous system, the endocrine system
	a. uses chemical signals as a means of communication.
	b. helps maintain equilibrium.
	c. sends messages to target organs.
	d. changes the metabolism of cells.
	2.	Pain receptors are at the distal ends of
	a. interneurons.
	b. intraneurons.
	c. sensory neurons.
	d. motor neurons.
	3.	Which of the following is not true of the nerve impulse? The nerve impulse
	a. is subject to a short refractory period before it can occur again.
	b. is slower in thick myelinated fibers.
	c. is also called an action potential.
	d. moves from neurofibril node to neurofibril node in myelinated fibers.
	4.	When comparing the interior of an axon at rest to the exterior, there is
	a. a charge difference.
	b. an ion concentration difference.
	c. both a charge and ion concentration difference.
	d. neither a charge nor an ion concentration difference.
	5.	Long-term use of cocaine causes an intense craving for the drug because the body has begun to make
	a. less dopamine.
	b. more dopamine.
	c. less anandamide.
	d. more anandamide.
	6.	Myelin is formed from
	a. dendrites.
	b. Schwann cells.
	c. axons.
	d. motor neurons.
	7.	Label the parts of the brain in the following illustration.
For questions 8–12, identify the part of the brain in the key that matches the description. Some answers may be used more than once. Some questions may have more than one answer.
Key:
	a. cerebrum
	b. diencephalon
	c. cerebellum
	d. brain stem
	8.	Regulates hunger, thirst, and sleep.
	9.	Receives sensory information from eyes and ears. 
	10.	Composed of two parts; mostly white matter.
	11.	Regulates heartbeat, breathing, and blood pressure.
	12.	Responsible for sensation, voluntary movement, and higher thought processes.
	13.	In contrast to exocrine glands, endocrine glands
	a. secrete products.
	b. induce a response by the body.
	c. utilize ducts.
	d. produce hormones.
	14.	Both the adrenal medulla and the adrenal cortex are
	a. endocrine glands.
	b. in the same organ.
	c. involved in our response to stress.
	d. All of these are correct. 
	15.	Diabetes type 1 is thought to result from a virus that
	a. interferes with gene expression in pancreatic cells.
	b. causes T cells to destroy the pancreatic islets.
	c. breaks down insulin.
	d. prevents the secretion of insulin by the pancreatic islets.
	16.	Label the parts of the endocrine system in the following illustration.
	17.	The cerebellum
	a. coordinates skeletal muscle movements.
	b. receives sensory input from the joints and muscles.
	c. receives motor input from the cerebral cortex.
	d. All of these are correct.
	18.	An interneuron can relay information
	a. from a sensory neuron to a motor neuron.
	b. only from a motor neuron to another motor neuron.
	c. only from a sensory neuron to another sensory neuron.
	d. None of these are correct.
	19.	The sympathetic division of the autonomic nervous system will
	a. increase heart rate and digestive activity.
	b. decrease heart rate and digestive activity.
	c. cause pupils to constrict.
	d. None of these are correct.
	20.	Effects of drugs can include
	a. prevention of neurotransmitter release.
	b. prevention of reuptake by the presynaptic membrane.
	c. blockages to a receptor.
	d. All of these are correct.
	e. None of these are correct.
	21.	Which of these correctly describes the distribution of ions on either side of an axon when it is not conducting a nerve impulse?
	a. more sodium ions (Na1) outside and more potassium ions (K1) inside
	b. more K1 outside and less Na1 inside
	c. charged protein outside; Na1 and K1 inside
	d. Na1 and K1 outside and water only inside
	e. chloride ions (Cl2) on the outside and K1 and Na1 on the inside
	22.	When the action potential begins, sodium gates open, allowing Na1 to cross the membrane. Now the polarity changes to
	a. negative outside and positive inside.
	b. positive outside and negative inside.
	c. neutral outside and positive inside.
	d. There is no difference in charge between outside and inside.
	23.	Transmission of the nerve impulse across a synapse is accomplished by the
	a. movement of Na1 and K1.
	b. release of a neurotransmitter by a dendrite.
	c. release of a neurotransmitter by an axon.
	d. release of a neurotransmitter by a cell body.
	e. Any one of these is correct.
	24.	The autonomic system has two divisions, called the
	a. CNS and PNS.
	b. somatic and skeletal systems.
	c. efferent and afferent systems.
	d. sympathetic and parasympathetic divisions.
	25.	The limbic system
	a. involves portions of the cerebral lobes and the diencephalon.
	b. is responsible for our deepest emotions, including pleasure, rage, and fear.
	c. is a system necessary to memory storage.
	d. is not directly involved in language and speech.
	e. All of these are correct.
	26.	Growth hormone is produced by the 
	a. posterior adrenal gland.
	b. posterior pituitary.
	c. anterior pituitary.
	d. kidneys.
	e. None of these are correct.
	27.	Glucagon causes 
	a. use of fat for energy.
	b. glycogen to be converted to glucose.
	c. use of amino acids to form fats.
	d. Both a and b are correct.
	e. None of these are correct.
	28.	Long-term complications of diabetes include
	a. blindness.
	b. kidney disease.
	c. circulatory disorders.
	d. All of these are correct.
	e. None of these are correct.
	29.	PTH causes the blood level of calcium to _________, and calcitonin causes it to _________.
	a. increase, not change
	b. increase, decrease
	c. decrease, also decrease
	d. decrease, increase
	e. not change, increase
Bioethical Issue
Recently, the Food and Drug Administration (FDA) approved the use of human growth hormone to treat “short stature.” This decision implies that short stature is a medical condition with a legitimate need to be treated. In this case, medical care is not treating a disease, but enhancing a feature of an otherwise healthy person. Proponents of the FDA decision say that administering growth hormone to short people will help them avoid discrimination and live a more normal life in a world designed for taller people. Opponents say that this decision may lead to slippery-slope scenarios in which medical treatments that make us smarter or faster are assumed to make us better. Do you think human growth hormone should be used to “cure shortness”? Typically, parents will need to make decisions about growth hormone treatments for their children, since the treatments are generally administered to preschoolers. Should parents be allowed to make decisions about treatments that will determine their children’s heights?
Understanding the Terms
acetylcholine (ACh)476
acetylcholinesterase 
(AChE)476
action potential475
Addison disease487
adrenal cortex487
adrenal gland487
adrenal medulla487
adrenocorticotropic hormone 
(ACTH)484
Alzheimer disease (AD)480
anterior pituitary484
antidiuretic hormone 
(ADH)485
autonomic system482
axon474
brain stem479
calcitonin486
cell body474
central nervous system 
(CNS)473
cerebellum479
cerebral cortex478
cranial nerve480
Cushing syndrome487
dendrite474
diabetes mellitus488
dorsal root ganglion481
endocrine gland483
epinephrine487
exophthalmic goiter486
ganglion480
glucagon487
glucocorticoid487
gonadotropic hormones 
(FSH and LH)484
growth hormone (GH)485
hypothalamic-releasing 
hormone484
hypothalamus479, 484
insulin487
integration476
interneuron474
limbic system480
medulla oblongata479
memory480
mineralocorticoid487
motor neuron474
myelin sheath474
negative feedback486
nerve480
neuron474
neurotransmitter476
norepinephrine (NE)476, 487
oxytocin484
pancreas487
pancreatic islets487
parasympathetic division482
parathyroid gland486
parathyroid hormone 
(PTH)486
peptide hormone484
peripheral nervous system 
(PNS)473
pituitary gland484
posterior pituitary485
prefrontal area479
primary motor area478
primary sensory area478
prolactin (PRL)484
reflex481
releasing hormone484
saltatory conduction475
sensory neuron474
simple goiter486
somatic system481
spinal cord478
spinal nerves481
steroid hormone483
sympathetic division482
synapse476
synaptic cleft476
tetany486
thalamus479
thyroid gland486
thyroid-stimulating hormone
(TSH)484
thyroxine (T4)486
tract478
Match the terms to these definitions:
a.	_______________	Portion of a neuron that conducts nerve impulses.
b.	_______________	Gap between an axon terminal and the dendrite of another neuron.
c.	_______________	Enzyme that breaks down a neurotransmitter.
d.	_______________	Structure that connects the brain to the spinal nerves.
e.	_______________	Region of the cerebral cortex responsible for critical thinking.
f.	_______________	Bundle of axons.
g.	_______________	Stimulate the gonads to produce gametes and sex hormones.
h.	_______________	Inner portion of an adrenal gland.
i.	_______________	Disorder that results when the adrenal cortex does not secrete enough hormone.
j.	_______________	Endocrine tissue in the pancreas.
If brain tissue is removed, it is possible to live with half a brain.
The nervous and endocrine systems control our behavior.
Brain tissue will die from lack of sleep faster than from starvation.
Figure 27.2Comparison of nervous systems.
Invertebrates, such as a planarian and an earthworm, as well as vertebrates, such as humans, have a central nervous system 
(e.g., brain) and a peripheral nervous system (nerves).
Figure 27.1Modes of action of the nervous and endocrine systems.
a. Nerve impulses passing along an axon cause the release of a neurotransmitter. The neurotransmitter, a chemical signal, causes the wall of an arteriole to constrict. 
b. The hormone insulin, a chemical signal, travels in the cardiovascular system from the pancreas to the liver, where it causes liver cells to store glucose as glycogen. 
Check Your Progress
	1.	Describe the function of the nervous system in planarians, and explain how it is anatomically different from that of humans.
	2.	
List the five trends toward complexity of the nervous system in animals.
Answers:1. The major function of the planarian nervous system is to bring about movement. The planarian nervous system is composed of two lateral nerve cords and transverse nerves that join them to form a ladderlike system. The human nervous system controls the muscular system and all the other systems. Humans have a well-developed central nervous system, which works in conjunction with the peripheral nervous system.2. The central nervous system processes incoming messages before sending out messages; neurons are specialized for carrying messages; the brain has specialized regions for receiving information from different parts of the body; the CNS can respond to both internal and external stimuli; and sense organs detect changes in the external environment.
Check Your Progress
	List the three major types of neurons and their functions.
Answer:Sensory neurons take nerve impulses from sensory receptors to the central nervous system. Interneurons carry nerve impulses between parts of the central nervous system. Motor neurons carry nerve impulses from the central nervous system to muscles or glands.
Figure 27.3Types of neurons.
A sensory neuron, an interneuron, and a motor neuron are drawn here to show their arrangement in the body. Only axons conduct nerve impulses. In a sensory neuron, a process that extends from the cell body divides into an axon that takes nerve impulses all the way from the dendrites to the CNS. In a motor neuron and interneuron the axon extends directly from the cell body. The axon of sensory and motor neurons is covered by a myelin sheath. All long axons have a myelin sheath.
Figure 27.4Conduction of action potentials in an unmyelinated axon.
a. Na+ and K+ each have their own gated channel protein by which they cross the axon’s membrane. b. During an action potential, Na+ enters the axon, and the charge difference between inside and outside reverses (blue); then K+ exits, and the charge difference is restored (red). The action potential moves from section to section in an unmyelinated axon. Only a few ions are exchanged at a time.
Figure 27.5Conduction of a nerve impulse in a myelinated axon. 
Action potentials can occur only at gaps in the myelin sheath called neurofibril nodes. This makes the speed of conduction much faster than in unmyelinated axons. In humans, all long axons are myelinated. 
Check Your Progress
	1.	Sequentially list the steps in an action potential.
	2.	
Explain why saltatory conduction is rapid.
	3.	Explain how a signal is carried across the synaptic cleft.
Answers:1. First: Na+ gates open and Na+ moves to the inside; the inside of the axon becomes positive. Second: K+ gates open, and K+ moves to the outside; the inside of the axon becomes negative again.2. Saltatory conduction occurs when axons are myelinated, allowing an action potential at one node to cause an action potential at the next node.3. Nerve impulses at the axon terminal cause synaptic vesicles to release a neurotransmitter into the synaptic cleft. The neurotransmitters then diffuse across the cleft and bind to a receptor proteins.
Figure 27.7Effect of cocaine on brain.
In a cocaine user, PET scans show that (a) the usual activity of the brain is (b) reduced. The color red indicates brain tissue is active. 
Figure 27.6Synapse structure and function.
Transmission across a synapse from one neuron to another occurs when a neurotransmitter is released, diffuses across a synaptic cleft, and binds to a receptor in the plasma membrane of the next neuron. Each axon releases only one type of neurotransmitter, symbolized here by a red ball.
Check Your Progress
	Compare and contrast the primary sensory area with the primary motor area of the cerebrum.
Answer:The primary sensory area receives information from the skin, skeletal muscles and joints. The primary motor area sends voluntary commands to skeletal muscles.
Figure 27.9Vertebrate brains.
a. A comparison of reptile, bird, and mammalian brains shows that the forebrain increased in size and complexity among these animals. b. The human brain.

Figure 27.10Functional regions of the cerebral cortex.
Specific areas of the cerebral cortex receive sensory input from particular sensory receptors, integrate various types of information, or send out motor commands to particular areas of the body.
Check Your Progress
	1.	Compare and contrast semantic memory with episodic memory.
	2.	
If a reflex action does not require the brain, why are we sometimes aware that a reflex has occurred?
Answers:1. Both are required for long-term memory. Semantic memory deals with numbers and words, while episodic memory involves people and events.2. Our awareness of a reflex is dependent on impulses that travel in tracts from the spinal cord to the brain or from sense organs to the brain.
Figure 27.11The limbic system.
The limbic system includes the diencephalon and parts of the cerebrum. It joins higher mental functions, such as reasoning, with more primitive feelings, such as fear and pleasure. Eating is a pleasurable activity for most people.
Figure 27.12A nerve.
A nerve contains the axons of many neurons.
Figure 27.13A reflex arc showing the path of a spinal reflex.
A stimulus (e.g., a pinprick) causes sensory receptors in the skin to generate nerve impulses that travel in sensory axons to the spinal cord. Interneurons integrate data from sensory neurons and then relay signals to motor neurons. Motor axons convey nerve impulses from the spinal cord to a skeletal muscle, which contracts. Movement of the hand away from the pin is the response to the stimulus.
Check Your Progress
	Explain why the parasympathetic division of the autonomic system is called the “housekeeper division.”
Answer:The parasympathetic division keeps the “house” in order by maintaining the internal responses associated with a relaxed state, such as pupil contraction, food digestion, and slow heartbeat.
Figure 27.14
Autonomic system.
The parasympathetic and sympathetic motor axons go to the same organs, but they have opposite effects. The parasympathetic division is active when we feel warm and cozy in the arms of someone who loves us (see photograph). The sympathetic division is active when we are stressed and feel threatened.
Figure 27.15The endocrine system.
Anatomical location of major endocrine glands in the body. 
Figure 27.16How 
hormones work. 
a. A steroid hormone (S) is a chemical signal that is able to enter the cell. Reception of this messenger causes the cell to synthesize a product by way of the cellular machinery for protein synthesis. 
b. A peptide hormone (P) is a “first messenger” that is received by a cell at the plasma membrane. Reception of the first messenger and a signal transduction pathway lead to a “second messenger” that changes the metabolism of the cell. 
Check Your Progress
	Explain how hormones induce metabolic changes in cells.
Answer:Steroid hormones enter the cell and stimulate genes to produce enzymes that alter cell activity. Peptide hormones induce an enzyme cascade that alters cell activity.
Figure 27.17Negative feedback inhibition. 
The hormones secreted by the thyroid (and also the adrenal cortex and gonads) feed back to inhibit the anterior pituitary and hypothalamic-releasing hormones so that their blood levels stay relatively constant.
Figure 27.18The hypothalamus and the pituitary.
(Left) The hypothalamus controls the secretions of the anterior pituitary, and the anterior pituitary controls the secretions of the thyroid gland, adrenal cortex, and gonads, which are also endocrine glands. Growth hormone and prolactin are also produced by the anterior pituitary. (Right) The hypothalamus produces two hormones, ADH and oxytocin, which are stored and secreted by the posterior pituitary.
Check Your Progress
	1.	
Compare and contrast prolactin with growth hormone.
	2.	Explain why a simple goiter results from a diet low in iodine.
Answers:1. Both are produced by the anterior pituitary and do not affect other endocrine glands. Prolactin stimulates the development of mammary glands and milk production. Growth hormone promotes skeletal and muscle growth.2. Iodine is a component of hormones produced by the thyroid gland. These hormones cannot be made unless iodine is present. Consequently, the thyroid receives constant stimulation from the anterior pituitary, which causes it to enlarge. The result is a simple goiter.
Figure 27.19Simple goiter.
An enlarged thyroid gland can result from too little iodine in the diet. The thyroid is under constant stimulation to produce more of its hormones and so it enlarges, resulting in a simple goiter.
Figure 27.21Cushing syndrome.
Cushing syndrome results from hypersecretion of hormones by the adrenal cortex possibly due to a tumor. a. Patient first diagnosed with Cushing syndrome. b. Four months later, after treatment.
Check Your Progress
	1.	Compare and contrast the adrenal medulla with the adrenal cortex.
	2.	
Contrast the function of insulin with that of glucagon.
	3.	Contrast diabetes type 1 with diabetes type 2.
Answers:1. Both are components of the adrenal glands and are controlled by the hypothalamus. The adrenal medulla provides rapid, short-term responses to stress, while the adrenal cortex provides long-term responses to stress.
2. Insulin lowers blood sugar levels by stimulating the uptake of glucose by cells. Glucagon raises blood sugar levels by stimulating the breakdown of glycogen to glucose.3. People with diabetes type 1 do not produce insulin, so they require daily insulin injections. People with diabetes type 2 produce insulin, but the liver and muscle cells do not respond to it as they should.
Figure 27.22Regulation of blood glucose level. 
Typical of hormones, insulin is regulated by negative feedback—once the blood glucose level is low, insulin is no longer secreted. The effect of insulin is countered by glucagon, which raises the blood glucose level. The two hormones work together to keep the blood glucose level relatively constant. 
Figure 27.8 Drug abuse.
Blood-borne diseases such as AIDS and hepatitis B pass from one drug abuser to another when they share needles.
Figure 27.20Exopthalmic goiter.
An exopthalmic goiter is so-named because enlargement of the thyroid gland can cause the eyes to protrude. In this individual only the left eye was affected. The overactive thyroid produces too much of its hormones and the individual is hyperactive and nervous.
affected eye